Insulin-Degrading Enzyme (IDE) (N-Term) Peptide
Quick Overview for Insulin-Degrading Enzyme (IDE) (N-Term) Peptide (ABIN8103119)
Target
Origin
Source
Application
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Protein Region
- N-Term
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Purpose
- IDE Peptide - N-terminal region
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Sequence
- LDVHIGSLSD PPNIAGLSHF CEHMLFLGTK KYPKENEYSQ FLSEHAGSSN
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Comment
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This is a synthetic peptide designed for use in combination with anti-IDE Antibody (ARP30652_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Buffer
- Lyophilized powder
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
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- IDE (Insulin-Degrading Enzyme (IDE))
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Background
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Background Information: This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion.
Alternative Symbols: FLJ35968, INSULYSIN
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Molecular Weight
- 118kDa
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Gene ID
- 3416
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NCBI Accession
- NP_004960
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UniProt
- P14735
Target
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