Neutrophil Cytosolic Factor 4, 40kDa (NCF4) (C-Term) Peptide
Quick Overview for Neutrophil Cytosolic Factor 4, 40kDa (NCF4) (C-Term) Peptide (ABIN8106447)
Target
Origin
Source
Application
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Protein Region
- C-Term
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Purpose
- NCF4 Peptide - C-terminal region
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Sequence
- PSLRPLPLTS PSHGSLSHSK APSGSQMSHN AVTSHQRPGW PGQPHSPFPH
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Comment
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This is a synthetic peptide designed for use in combination with anti-NCF4 Antibody(ARP58922_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Buffer
- Lyophilized powder
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
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- NCF4 (Neutrophil Cytosolic Factor 4, 40kDa (NCF4))
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Background
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Background Information: NCF4 is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Alternative Symbols: MGC3810, NCF, P40PHOX, SH3PXD4
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Molecular Weight
- 39kDa
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Gene ID
- 4689
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NCBI Accession
- NP_038202
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UniProt
- A8K4F9
Target
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