Neutrophil Cytosolic Factor 4, 40kDa (NCF4) (C-Term) Peptide
NCF4
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all NCF4 products
- NCF4 (Neutrophil Cytosolic Factor 4, 40kDa (NCF4))
- Protein Region
- C-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- PSLRPLPLTS PSHGSLSHSK APSGSQMSHN AVTSHQRPGW PGQPHSPFPH
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-NCF4 Antibody(ARP58922_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- NCF4 (Neutrophil Cytosolic Factor 4, 40kDa (NCF4))
- Synonyms
- p40phox Peptide, AI451400 Peptide, NCF Peptide, P40PHOX Peptide, SH3PXD4 Peptide, neutrophil cytosolic factor 4 Peptide, ncf4 Peptide, Ncf4 Peptide, NCF4 Peptide
- Background
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NCF4 is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Alias Symbols: MGC3810, NCF, P40PHOX, SH3PXD4
Protein Interaction Partner: CORO1A,CYBA,CYBB,MSN,NCF1,NCF2,PRKCD,TXN,XRCC6,MSN,NCF1,NCF2,PRKDC,TXN,XRCC6
Protein Size: 348 - Molecular Weight
- 39 kDa
- Gene ID
- 4689
- NCBI Accession
- NM_013416, NP_038202
- UniProt
- A8K4F9
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