Ribonucleotide Reductase M2 B (TP53 Inducible) (RRM2B) (C-Term) Peptide
Quick Overview for Ribonucleotide Reductase M2 B (TP53 Inducible) (RRM2B) (C-Term) Peptide (ABIN8110592)
Target
Origin
Source
Application
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Protein Region
- C-Term
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Purpose
- RRM2B Peptide - C-terminal region
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Sequence
- IEFVADRLLV ELGFSKVFQA ENPFDFMENI SLEGKTNFFE KRVSEYQRFA
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Comment
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This is a synthetic peptide designed for use in combination with anti- RRM2B Antibody (ARP87556_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Buffer
- Lyophilized powder
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
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- RRM2B (Ribonucleotide Reductase M2 B (TP53 Inducible) (RRM2B))
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Background
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Background Information: This gene encodes the small subunit of a p53-inducible ribonucleotide reductase. This heterotetrameric enzyme catalyzes the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates. The product of this reaction is necessary for DNA synthesis. Mutations in this gene have been associated with autosomal recessive mitochondrial DNA depletion syndrome, autosomal dominant progressive external ophthalmoplegia-5, and mitochondrial neurogastrointestinal encephalopathy. Alternatively spliced transcript variants have been described.
Alternative Symbols: P53R2, MTDPS8A, MTDPS8B
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Molecular Weight
- 32 kDa
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Gene ID
- 50484
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NCBI Accession
- NP_001165948
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UniProt
- Q7LG56
Target
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