Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR) Peptide
SIGIRR
Host: Synthetic
BP, IHC, WB
Catalog No. ABIN8111779
$145.08
Plus shipping costs $50.00
100 μg
Shipping to:
United States
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Quick Overview for Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR) Peptide (ABIN8111779)
Target
SIGIRR
(Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR))
Source
Synthetic
Application
Blocking Peptide (BP), Immunohistochemistry (IHC), Western Blotting (WB)
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Purpose
- SIGIRR Peptide
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Comment
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This is a synthetic peptide designed for use in combination with anti-SIGIRR antibody ( ARP49664_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Buffer
- Lyophilized powder
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
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- SIGIRR (Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR))
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Background
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Background Information: SIGIRR acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. It attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through a TIR-TIR domain interaction with TLR4. Through its extracellular domain it interferes with the heterodimerization of Il1R1 and IL1RAP.
Alternative Symbols: MGC110992, TIR8
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Molecular Weight
- 25kDa
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Gene ID
- 59307
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UniProt
- Q6IA17
Target
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