Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR) Peptide
SIGIRR
Reactivity: Human
Host: Synthetic
BP, IHC, WB
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- Target See all SIGIRR products
- SIGIRR (Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR))
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Immunohistochemistry (IHC), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-SIGIRR antibody (Catalog #: ARP49664_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- SIGIRR (Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR))
- Synonyms
- TIR8 Peptide, AI256711 Peptide, sc:d148 Peptide, RGD1306732 Peptide, single Ig and TIR domain containing Peptide, single immunoglobulin and toll-interleukin 1 receptor (TIR) domain Peptide, SIGIRR Peptide, Sigirr Peptide, sigirr Peptide
- Background
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SIGIRR acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. It attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through a TIR-TIR domain interaction with TLR4. Through its extracellular domain it interferes with the heterodimerization of Il1R1 and IL1RAP.
Alias Symbols: MGC110992, TIR8
Protein Interaction Partner: ENO2,IL1R1,IRAK1,RPN1,SIGIRR,TLR4,TLR5,TLR9,TRAF6,ENO2,IL1R1,IRAK1,SIGIRR,TLR4,TRAF6
Protein Size: 224 - Molecular Weight
- 25 kDa
- Gene ID
- 59307
- UniProt
- Q6IA17
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