Vacuolar-sorting Protein SNF8 (SNF8) (N-Term) Peptide
Quick Overview for Vacuolar-sorting Protein SNF8 (SNF8) (N-Term) Peptide (ABIN8115655)
Target
Origin
Source
Application
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Protein Region
- N-Term
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Purpose
- Snf8 Peptide - N-terminal region
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Sequence
- GTVLAEDQLA QMSKQLDMFK TNLEEFASKH KQEIRKNPEF RVQFQDMCAT
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Comment
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This is a synthetic peptide designed for use in combination with anti-Snf8 Antibody (ARP32857_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Buffer
- Lyophilized powder
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
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- SNF8 (Vacuolar-sorting Protein SNF8 (SNF8))
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Background
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Background Information: Snf8 is required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization. It is a component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL.
Alternative Symbols: D11moh34, MGC105799, RGD1310144
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Molecular Weight
- 28kDa
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Gene ID
- 287645
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NCBI Accession
- NP_001007805
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UniProt
- Q5RK19
Target
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