Apolipoprotein E (APOE) (N-Term) Peptide
APOE
Reactivity: Human
Host: Synthetic
BP, IHC, WB
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- Target See all APOE products
- APOE (Apolipoprotein E (APOE))
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Immunohistochemistry (IHC), Western Blotting (WB)
- Sequence
- LMDETMKELK AYKSELEEQL TPVAEETRAR LSKELQAAQA RLGADMEDVC
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-APOE Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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Apolipoprotein E (APOE) peptide
APOE Reactivity: Human Host: Synthetic BP, Imm
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- APOE (Apolipoprotein E (APOE))
- Synonyms
- ad2 Peptide, apoprotein Peptide, im:7036787 Peptide, wu:fb69a05 Peptide, zgc:110064 Peptide, apoe Peptide, AI255918 Peptide, AD2 Peptide, LDLCQ5 Peptide, LPG Peptide, APOEA Peptide, Apo-E Peptide, apolipoprotein E Peptide, apolipoprotein Ea Peptide, apoe Peptide, apoea Peptide, Apoe Peptide, APOE Peptide
- Background
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Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.
Alias Symbols: AD2, LDLCQ5, LPG, MGC1571
Protein Size: 317 - Molecular Weight
- 34 kDa
- Gene ID
- 348
- NCBI Accession
- NM_000041, NP_000032
- UniProt
- P02649
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