CD274 (PD-L1) (C-Term) Peptide
PD-L1
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all PD-L1 products
- PD-L1 (CD274 (PD-L1))
- Protein Region
- C-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- ELIRDYNSSR EDSLQDAWDY VQAQVKCCGW VSFYNWTDNA ELMNRPEVTY
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-CD82 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- PD-L1 (CD274 (PD-L1))
- Synonyms
- B7-H Peptide, B7H1 Peptide, PD-L1 Peptide, PDCD1L1 Peptide, PDCD1LG1 Peptide, PDL1 Peptide, A530045L16Rik Peptide, B7h1 Peptide, Pdcd1l1 Peptide, Pdcd1lg1 Peptide, Pdl1 Peptide, RGD1566211 Peptide, CD274 molecule Peptide, CD274 antigen Peptide, programmed cell death 1 ligand 2 Peptide, CD274 Peptide, Cd274 Peptide, PDCD1LG2 Peptide
- Background
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This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Alias Symbols: 4F9, C33, GR15, IA4, KAI1, R2, SAR2, ST6, TSPAN27
Protein Interaction Partner: BCL3,CTNNB1,KAT5,MAP3K1,NCOR1,NFKB1,POLR2A,RUVBL1,RUVBL2,TAB2,CANX,CD19,CD4,CD63,EGFR,ERBB2,ERBB3,HBEGF,HLA-DMA,HLA-DMB,HLA-DRA,IGSF8,ITGA3,ITGA4,ITGA6,ITGB1,ITGB2,LRP1,NUP88,PTGFRN,VANGL1,CD151,CD19,CD4,CD46,CD63,CD9,EGFR,ERBB2,ERBB3,HBEGF,HLA-DMB,HLA-DO
Protein Size: 242 - Molecular Weight
- 27 kDa
- Gene ID
- 3732
- NCBI Accession
- NM_001024844
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