Cochlin (COCH) (N-Term) Peptide
COCH
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all COCH products
- COCH (Cochlin (COCH))
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- AHPPTGKRLK KTPEKKTGNK DCKADIAFLI DGSFNIGQRR FNLQKNFVGK
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-COCH Antibody(ARP59585_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- COCH (Cochlin (COCH))
- Synonyms
- AW122937 Peptide, Coch-5B2 Peptide, D12H14S564E Peptide, COCH-5B2 Peptide, COCH5B2 Peptide, DFNA9 Peptide, cochlin Peptide, Coch Peptide, COCH Peptide
- Background
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The protein encoded by this gene is highly conserved in human, mouse, and chicken, showing 94 % and 79 % amino acid identity of human to mouse and chicken sequences, respectively. Hybridization to this gene was detected in spindle-shaped cells located along nerve fibers between the auditory ganglion and sensory epithelium. These cells accompany neurites at the habenula perforata, the opening through which neurites extend to innervate hair cells. This and the pattern of expression of this gene in chicken inner ear paralleled the histologic findings of acidophilic deposits, consistent with mucopolysaccharide ground substance, in temporal bones from DFNA9 (autosomal dominant nonsyndromic sensorineural deafness 9) patients. Mutations that cause DFNA9 have been reported in this gene. Alternative splicing results in multiple transcript variants encoding the same protein. Additional splice variants encoding distinct isoforms have been described but their biological validities have not been demonstrated.
Alias Symbols: COCH-5B2, COCH5B2, DFNA9
Protein Size: 550 - Molecular Weight
- 57 kDa
- Gene ID
- 1690
- NCBI Accession
- NM_001135058, NP_001128530
- UniProt
- O43405
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