Cochlin (COCH) Peptide
COCH
Reactivity: Mammalian
Host: Synthetic
BP, WB, IHC
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- Target See all COCH products
- COCH (Cochlin (COCH))
- Peptide Type
- Synthetic
- Origin
- Mammalian
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
- Sequence
- AHPPTGKRLK KTPEKKTGNK DCKADIAFLI DGSFNIGQRR FNLQKNFVGK
- Characteristics
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A synthetic peptide for use as a blocking control in assays to test for specificity of COCH antibody,
Alternative Names: COCH control peptide, COCH antibody Blocking Peptide, Anti-COCH Blocking Peptide, coagulation factor C homolog, cochlin, Limulus polyphemus Blocking Peptide, COCH-5B2 Blocking Peptide, COCH5B2 Blocking Peptide, DFNA9 Blocking Peptide
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- Application Notes
- Optimal conditions should be determined by the investigator
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 µL of distilled water for a final peptide concentration is 1 mg/mL.
- Buffer
- PBS
- Handling Advice
- Avoid repeated freeze/thaw cycles.
- Storage
- -20 °C
- Storage Comment
- Store at -20 °C long term.
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- Target
- COCH (Cochlin (COCH))
- Synonyms
- AW122937 Peptide, Coch-5B2 Peptide, D12H14S564E Peptide, COCH-5B2 Peptide, COCH5B2 Peptide, DFNA9 Peptide, cochlin Peptide, Coch Peptide, COCH Peptide
- Background
- The protein encoded by this gene is highly conserved in human, mouse, and chicken, showing 94 % and 74 % amino acid identity of human to mouse and chicken sequences, respectively. Hybridization to this gene was detected in spindle-shaped cells located along nerve fibers between the auditory ganglion and sensory epithelium. These cells accompany neurites at the habenula perforata, the opening through which neurites extend to innervate hair cells. This and the pattern of expression of this gene in chicken inner ear paralleled the histologic findings of acidophilic deposits, consistent with mucopolysaccharide ground substance, in temporal bones from DFNA9 (autosomal dominant nonsyndromic sensorineural deafness 9) patients. Mutations that cause DFNA9 have been reported in this gene. Alternative splicing results in multiple transcript variants encoding the same protein. Additional splice variants encoding distinct isoforms have been described but their biological validities have not been demonstrated.
- Molecular Weight
- 57 kDa
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