Deoxynucleotidyltransferase, terminal (DNTT) Peptide
DNTT
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all TdT (DNTT) products
- TdT (DNTT) (Deoxynucleotidyltransferase, terminal (DNTT))
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-DNTT antibody (Catalog #: ARP52031_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- TdT (DNTT) (Deoxynucleotidyltransferase, terminal (DNTT))
- Synonyms
- TdT Peptide, TDT Peptide, BB160593 Peptide, Tdt Peptide, dntt-A Peptide, dntt Peptide, DNA nucleotidylexotransferase Peptide, deoxynucleotidyltransferase, terminal Peptide, DNA nucleotidylexotransferase L homeolog Peptide, terminal deoxynucleotidyl transferase Peptide, DNTT Peptide, dntt Peptide, Dntt Peptide, dntt.L Peptide, tdt Peptide
- Background
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DNTT is a template-independent DNA polymerase that catalyzes the addition of deoxynucleotides to the 3'-hydroxyl terminus of oligonucleotide primers. In vivo, DNTT is expressed in a restricted population of normal and malignant pre-B and pre-T lymphocytes during early differentiation, where it generates antigen receptor diversity by synthesizing non-germ line elements (N-regions) at the junctions of rearranged Ig heavy chain and T cell receptor gene segments. This gene is a member of the DNA polymerase type-X family and encodes a template-independent DNA polymerase that catalyzes the addition of deoxynucleotides to the 3'-hydroxyl terminus of oligonucleotide primers. In vivo, the encoded protein is expressed in a restricted population of normal and malignant pre-B and pre-T lymphocytes during early differentiation, where it generates antigen receptor diversity by synthesizing non-germ line elements (N-regions) at the junctions of rearranged Ig heavy chain and T cell receptor gene segments. Alternatively spliced transcript variants encoding different isoforms of this gene have been described.
Alias Symbols: TDT
Protein Interaction Partner: DNTTIP1,DNTTIP2,PCNA,PRPF19,XRCC6,ABTB2,CUL3,DNTTIP2,PCNA,PRPF19,UBC,XRCC6
Protein Size: 509 - Molecular Weight
- 58 kDa
- Gene ID
- 1791
- NCBI Accession
- NM_004088, NP_004079
- UniProt
- P04053
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