G protein beta subunit-like (GBL) (Middle Region) Peptide
GBL
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all GBL products
- GBL (G protein beta subunit-like (GBL))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- CAFSGDSQYI VTASSDNLAR LWCVETGEIK REYGGHQKAV VCLAFNDSVL
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-GBL Antibody(ARP57630_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- GBL (G protein beta subunit-like (GBL))
- Synonyms
- gbl Peptide, lts8 Peptide, GBL Peptide, GbetaL Peptide, LST8 Peptide, POP3 Peptide, WAT1 Peptide, 0610033N12Rik Peptide, AA409454 Peptide, AI505104 Peptide, AI851821 Peptide, Gbl Peptide, fi37e04 Peptide, wu:fi37e04 Peptide, zgc:55455 Peptide, zgc:85668 Peptide, MTOR associated protein, LST8 homolog L homeolog Peptide, MTOR associated protein, LST8 homolog Peptide, MTOR associated protein, LST8 homolog (S. cerevisiae) Peptide, mlst8.L Peptide, MLST8 Peptide, Mlst8 Peptide, mlst8 Peptide
- Background
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GBL is the subunit of both mTORC1 and mTORC2, which regulate cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino-acids. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'.
Alias Symbols: MGC111011, GBL, LST8, POP3, WAT1, GbetaL
Protein Interaction Partner: MTOR,RPTOR,RHEB,CCT2,KRT85,MTOR,RPTOR
Protein Size: 326 - Molecular Weight
- 36 kDa
- Gene ID
- 64223
- NCBI Accession
- NM_022372, NP_071767
- UniProt
- Q9BVC4
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