Poly(rC) Binding Protein 1 (PCBP1) (Middle Region) Peptide
PCBP1
Reactivity: Human
Host: Synthetic
BP, WB, IHC
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- Target See all PCBP1 products
- PCBP1 (Poly(rC) Binding Protein 1 (PCBP1))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
- Sequence
- PHATHDLEGP PLDAYSIQGQ HTISPLDLAK LNQVARQQSH FAMMHGGTGF
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-PCBP1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- PCBP1 (Poly(rC) Binding Protein 1 (PCBP1))
- Synonyms
- PCBP1 Peptide, HNRPE1 Peptide, HNRPX Peptide, hnRNP-E1 Peptide, hnRNP-X Peptide, hnRNP E1 Peptide, WBP17 Peptide, [a]CP-1 Peptide, alphaCP-1 Peptide, RGD1561319 Peptide, poly(rC) binding protein 1 Peptide, poly(rC) binding protein 1 L homeolog Peptide, poly(rC)-binding protein 1 Peptide, PCBP1 Peptide, pcbp1.L Peptide, LOC100388387 Peptide, Pcbp1 Peptide
- Background
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PCBP1 appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. PCBP1 is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.This intronless gene is thought to be generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 has paralogues PCBP3 and PCBP4 which is thought to arose as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding proteins. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.
Alias Symbols: HNRPE1, HNRPX, hnRNP-E1, hnRNP-X
Protein Size: 356 - Molecular Weight
- 37 kDa
- Gene ID
- 5093
- NCBI Accession
- NM_006196, NP_006187
- UniProt
- Q15365
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