Timeless Homolog (TIMELESS) Peptide
TIMELESS
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all TIMELESS products
- TIMELESS (Timeless Homolog (TIMELESS))
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-TIMELESS antibody (Catalog #: ARP38403_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- TIMELESS (Timeless Homolog (TIMELESS))
- Synonyms
- TIM Peptide, TIM1 Peptide, hTIM Peptide, C77407 Peptide, Debt69 Peptide, tim Peptide, CG3234 Peptide, Dmel\\CG3234 Peptide, Ritsu Peptide, Tim Peptide, dTIM Peptide, dTim Peptide, dtim Peptide, mel_tim Peptide, rit Peptide, tim1 Peptide, XTimeless1 Peptide, timeless Peptide, timelessb Peptide, TIMELESS Peptide, MXC20.14 Peptide, MXC20_14 Peptide, htim Peptide, im:6903167 Peptide, wu:fa95g04 Peptide, wu:fd23d07 Peptide, timeless circadian regulator Peptide, timeless circadian clock 1 Peptide, timeless Peptide, timeless circadian clock Peptide, timeless circadian clock S homeolog Peptide, timeless family protein Peptide, TIMELESS Peptide, Timeless Peptide, tim Peptide, timeless.S Peptide, Tim Peptide, ATIM Peptide, timeless Peptide, LOC100328917 Peptide
- Background
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The human Timeless protein interacts with both the circadian clock protein cryptochrome 2 and with the cell cycle checkpoint proteins Chk1 and the ATR-ATRIP complex and plays an important role in the DNA damage checkpoint response. Down-regulation of Timeless in human cells seriously compromises replication and intra-S checkpoints, indicating an intimate connection between the circadian cycle and the DNA damage checkpoints that is in part mediated by the Timeless protein.
Alias Symbols: TIM, TIM1, hTIM
Protein Interaction Partner: CRY1,PER1,PER2,TIPIN,ATRIP,CHEK1,CLSPN,CRY2,Clock,PCNA,Per1,Per2,TIPIN,per
Protein Size: 1208 - Molecular Weight
- 139 kDa
- Gene ID
- 8914
- NCBI Accession
- NM_003920, NP_003911
- UniProt
- Q9UNS1
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