Protein Tob1 (TOB1) (Middle Region) Peptide
TOB1
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all Protein Tob1 (TOB1) products
- Protein Tob1 (TOB1)
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- DLLKQKAISS SMHSLYGLGL GSQQQPQQQQ QPAQPPPPPP PPQQQQQQKT
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-TOB1 Antibody(ARP52105_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- Protein Tob1 (TOB1)
- Synonyms
- Tob Peptide, Trob Peptide, APRO5 Peptide, APRO6 Peptide, PIG49 Peptide, TOB Peptide, TROB Peptide, TROB1 Peptide, tob1 Peptide, tob1l Peptide, wu:fb54d02 Peptide, wu:fb98h12 Peptide, wu:fd15f10 Peptide, zgc:65837 Peptide, transducer of ErbB-2.1 Peptide, transducer of ERBB2, 1 Peptide, transducer of ERBB2, 1a Peptide, transducer of ERBB2, 1 S homeolog Peptide, transducer of ERBB2, 1b Peptide, Tob1 Peptide, TOB1 Peptide, tob1a Peptide, tob1.S Peptide, tob1b Peptide
- Background
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This gene encodes a member of the tob/btg1 family of anti-proliferative proteins that have the potential to regulate cell growth. When exogenously expressed, this protein supresses cell growth in tissue culture. The protein undergoes phophorylation by a serine/threonine kinase, 90 kDa ribosomal S6 kinase. Interactions of this protein with the v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 gene product p185 interferes with growth suppression. This protein inhibits T cell proliferation and transcription of cytokines and cyclins. The protein interacts with both mothers against decapentaplegic Drosophila homolog 2 and 4 to enhance their DNA binding activity. This interaction inhibits interleukin 2 transcription in T cells.
Alias Symbols: APRO6, MGC104792, MGC34446, PIG49, TOB, TROB, TROB1
Protein Interaction Partner: CNOT7,ERBB2,MAPK1,MARCKS,SCMH1,SETDB1,SMAD1,SMAD2,SMAD3,SMAD4,SMAD5,SMAD6,SMAD9,CNOT7,MAPK1,MAPK9,MARCKS,PABPC1,RPS6KA1,SCMH1,SETDB1,SKP2,SMAD1,SMAD4,SMAD5,SMAD9,UBC
Protein Size: 345 - Molecular Weight
- 38 kDa
- Gene ID
- 10140
- NCBI Accession
- NM_005749, NP_005740
- UniProt
- P50616
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