Ubiquitin-Like Modifier Activating Enzyme 3 (UBA3) (N-Term) Peptide
UBA3
Reactivity: Human
Host: Synthetic
BP, IHC, WB
Catalog No. ABIN985798
$160.46
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100 μg
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Quick Overview for Ubiquitin-Like Modifier Activating Enzyme 3 (UBA3) (N-Term) Peptide (ABIN985798)
Target
UBA3
(Ubiquitin-Like Modifier Activating Enzyme 3 (UBA3))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Immunohistochemistry (IHC), Western Blotting (WB)
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Protein Region
- N-Term
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-UBA3 antibody (Catalog #: ARP50493_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- UBA3 (Ubiquitin-Like Modifier Activating Enzyme 3 (UBA3))
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Background
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UBA3 is a catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. UBA3 down-regulates steroid receptor activity. UBA3 is necessary for cell cycle progression.The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Alias Symbols: DKFZp566J164, MGC22384, UBE1C, hUBA3
Protein Interaction Partner: NAE1,CHD3,NAE1,NEDD8,UBE2M,CHD3,NAE1,NEDD8,UBE2M,UIMC1
Protein Size: 463 -
Molecular Weight
- 52 kDa
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Gene ID
- 9039
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NCBI Accession
- NM_003968, NP_003959
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UniProt
- Q8TBC4
Target
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