Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7) (Middle Region) Peptide
USP7
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN985997
$160.46
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100 μg
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Quick Overview for Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7) (Middle Region) Peptide (ABIN985997)
Target
USP7
(Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Sequence
- RVLLDNVENK MKGTCVEGTI PKLFRGKMVS YIQCKEVDYR SDRREDYYDI
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-USP7 Antibody,. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- USP7 (Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7))
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Background
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USP7 is a hydrolase that deubiquitinates target proteins such as FOXO4, TP53, MDM2, PTEN and DAXX. Together with DAXX, USP7 prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination and proteasomal degradation. USP7 deubiquitinates TP53 and MDM2 and strongly stabilizes TP53 even in the presence of excess MDM2, and also induces TP53-dependent cell growth repression and apoptosis. Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on TP53 and inhibits FOXO4-induced transcriptional activity. In association with DAXX, USP7 is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, both processes that are counteracted by PML. USP7 is involved in cell proliferation during early embryonic development. USP7 contributes to the overall stabilization and trans-activation capability of the herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110 during HSV-1 infection.
Alias Symbols: HAUSP, TEF1
Protein Interaction Partner: HHV4gp098,MDM2,MDM4,TP53,ACD,ARNT2,ATXN1,BCOR,BEND5,CREB3L3,DAXX,DNAJA3,EWSR1,HECW1,HERPUD1,HTRA2,KLHL8,MAGEE1,MARCH7,MDM2,MDM4,NECAB2,PEG3,PICK1,PLEKHO1,PPL,RADIL,RNF220,SYVN1,TANK,TBCB,TMPO,TP53,TRAF1,TRAF2,TRAF3,TRAF4,TRAF5,TRAF6,TRIM22,TRO,USP7,WWP2,Z
Protein Size: 1102 -
Molecular Weight
- 128 kDa
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Gene ID
- 7874
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NCBI Accession
- NM_003470, NP_003461
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UniProt
- Q93009
Target
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