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PHC1 Products

(Polyhomeotic-Like 1 (PHC1))

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This gene is a homolog of the Drosophila polyhomeotic gene, which is a member of the Polycomb group of genes. The gene product is a component of a multimeric protein complex that contains EDR2 and the vertebrate Polycomb protein BMH1. The gene product, the EDR2 protein, and the Drosophila polyhomeotic protein share 2 highly conserved domains, named homology domains I and II. These domains are involved in protein-protein interactions and may mediate heterodimerization of the protein encoded by this gene and the EDR2 protein. [provided by RefSeq, Jul 2008].

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Featured PHC1 Categories

PHC1 Antibodies

High quality antibodies with extensive validation data.

Recommended PHC1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, FACS
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Cat. No. ABIN1724838
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Human
Application WB, IP
Validations
  • (1)
  • (3)
Cat. No. ABIN515164
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
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Cat. No. ABIN515166
Quantity 100 μg
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Recommended PHC1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
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Reactivity Human
Source Tobacco (Nicotiana tabacum)
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Cat. No. ABIN3094531
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
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Cat. No. ABIN3135569
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our PHC1 products

Awad, Al-Dosari, Al-Yacoub, Colak, Salih, Alkuraya, Poizat: "Mutation in PHC1 implicates chromatin remodeling in primary microcephaly pathogenesis." in: Human molecular genetics, Vol. 22, Issue 11, pp. 2200-13, (2013) (PubMed).

Lin, Shen, Li, Tang, Gu, Chen, Hu, Rice, Lu, Wu: "Proteomic and functional analyses reveal the role of chromatin reader SFMBT1 in regulating epigenetic silencing and the myogenic gene program." in: The Journal of biological chemistry, Vol. 288, Issue 9, pp. 6238-47, (2013) (PubMed).

Boyer, Plath, Zeitlinger, Brambrink, Medeiros, Lee, Levine, Wernig, Tajonar, Ray, Bell, Otte, Vidal, Gifford, Young, Jaenisch: "Polycomb complexes repress developmental regulators in murine embryonic stem cells." in: Nature, Vol. 441, Issue 7091, pp. 349-53, (2006) (PubMed).

Miyagishima, Isono, Fujimura, Iyo, Takihara, Masumoto, Vidal, Koseki: "Dissociation of mammalian Polycomb-group proteins, Ring1B and Rae28/Ph1, from the chromatin correlates with configuration changes of the chromatin in mitotic and meiotic prophase." in: Histochemistry and cell biology, Vol. 120, Issue 2, pp. 111-9, (2003) (PubMed).

Synonyms and alternative names related to PHC1

polyhomeotic homolog 1 (Phc1), polyhomeotic homolog 1 (PHC1), polyhomeotic-like 1 (Drosophila) (Phc1), AW557034, Edr, EDR1, Edr1, HPH1, Mph1, Rae-28, RAE28, rae28

Protein level used designations for PHC1

  • polyhomeotic-like 1
  • polyhomeotic-like protein 1
  • early development regulator 1 (homolog of polyhomeotic 1)
  • early development regulatory protein 1
  • early development regulator1 (homolog of polyhomeotic 1)
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