Protein Summary

This gene encodes a highly conserved glycoprotein which is a precursor for 4 cleavage products: saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease, Tay-Sachs disease, and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants encoding different isoforms.

Alternative names and synonyms associated with Prosaposin (PSAP)

• prosaposin (PSAP) antibody
• prosaposin (Psap) antibody
• prosaposin (psap) antibody
• prosaposin (LOC100011417) antibody
• prosaposin (LOC100304726) antibody
• Show all gene names
• prosaposin (LOC100526719) antibody

• AI037048 antibody
• cb759 antibody
• GLBA antibody
• SAP1 antibody
• SGP-1 antibody
• Show all synonym aliases
• SGP1A antibody
• wu:fa14a06 antibody
• wu:fb36e02 antibody
• wu:fb58g07 antibody

Protein level used designations for anti-Prosaposin (PSAP) Antibodies

proactivator polypeptide , sphingolipid activator protein-1 , snoRNA MBII-198 , sulfated glycoprotein 1 , prosaposin (sulfated glycoprotein, sphingolipid hydrolase activator) , prosaposin (variant Gaucher disease and variant metachromatic leukodystrophy) , prosaposin , proactivator polypeptide-like