CD200R1 Protein (AA 27-266) (His tag)

Catalog No. ABIN1096305

This Recombinant CD200R1 protein is produced in Human Cells.

Quick Overview for CD200R1 Protein (AA 27-266) (His tag) (ABIN1096305)

Target: CD200R1 (CD200 Receptor 1 (CD200R1))

Protein Type: Recombinant

Origin: Human

Source: Human Cells

Purity: > 95 % as determined by reducing SDS-PAGE.

Product Details

Protein Characteristics: AA 27-266

Purification tag / Conjugate: This CD200R1 protein is labelled with His tag.

Purpose: Recombinant Human CD200 Receptor 1/CD200R1 (C-6His)

Sequence: AAQPNNSLML QTSKENHALA SSSLCMDEKQ ITQNYSKVLA EVNTSWPVKM ATNAVLCCPP IALRNLIIIT WEIILRGQPS CTKAYKKETN ETKETNCTDE RITWVSRPDQ NSDLQIRTVA ITHDGYYRCI MVTPDGNFHR GYHLQVLVTP EVTLFQNRNR TAVCKAVAGK PAAHISWIPE GDCATKQEYW SNGTVTVKST CHWEVHNVST VTCHVSHLTG NKSLYIELLP VPGAKKSAKL VDHHHHHH

Characteristics:

Recombinant Human CD200 Receptor 1/CD200R1 (C-6His)

Sterility: 0.2 μm filtered

Endotoxin Level: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

Handling Advice: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Storage: 4 °C/-20 °C/-80 °C

Storage Comment: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: CD200R1 (CD200 Receptor 1 (CD200R1))

Alternative Name: CD200 R1

Background: Recombinant Human CD200 R1 is produced with our mammalian expression system in human cells. The target protein is expressed with sequence (Met29-Leu325) of Human CD200 R1 fused with a polyhistidine tag at the C-terminus.
Cell surface glycoprotein CD200 Receptor 1 (CD200R1) is the receptor for the CD200 (OX-2) membrane glycoprotein. CD200R1 contains one C2- type Ig-like domain and one V-type Ig-like domain within its extracellular domain and a PTB-signaling motif in cytoplasmic domain. CD200R1 and CD200 associate via their respective N-terminal Ig-like domains. CD200R1 is restricted primarily to mast cells, basophils, macrophages, and dendritic cells. It propagates inhibitory signals despite its lacking a cytoplasmic ITIM (immunoreceptor tyrosinebased inhibitory motif). The receptor-substrate interaction may function as a myeloid downregulatory signal.

Molecular Weight: 25.22 kDa

UniProt: Q8TD46