HMGB1 Protein (BoxA Domain)
(1 reference)Quick Overview for HMGB1 Protein (BoxA Domain) (ABIN1176814)
Target
See all HMGB1 ProteinsProtein Type
Biological Activity
Origin
Source
Application
Purity
-
-
Protein Characteristics
- BoxA Domain
-
Sequence
- MGKGDPKKPR GKMSSYAFFV QTCREEHKKK HPDASVNFSE FSKKCSERWK TMSAKEKGKF EDMAKADKAR YEREMKTYIP PKGETKKKF
-
Characteristics
- BoxA is an antagonist for HMGB1 and appears to inhibit all its activities, depending from all receptors. Injection of 600 µg BoxA in the mouse protects against sepsis in a peritonitis model and from hepatitis in a mouse model of HBV infection (Sitia et al 2007). BoxA (10 µg/mL) inhibits maturation, survival and Th1 differentiation of dendritic cells and T cell proliferation.It contains only trace amounts of LPS (<0.4 ng/mg protein), and it is tested for the ability to inhibit the chemotactic activity of HMGB1 on fibroblasts.
-
Purification
- Purified
-
Endotoxin Level
- The purified protein is free from LPS (Cambrex Limulus Amoebocyte Assay QCL-1000, <0.4 ng LPS per mg protein).
-
-
Want other Options for this Protein ?
!Discover Our Predefined Custom Proteins and Custom Protein Services!Your project requires further customization? Contact us and discover our custom protein solutions
-
High Mobility Group Box 1 (HMGB1) (AA 1-215) protein (GST tag)
HMGB1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
High Mobility Group Box 1 (HMGB1) (AA 1-215) protein (His tag)HMGB1 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
High Mobility Group Box 1 (HMGB1) (AA 1-215) protein (His tag,Biotin)HMGB1 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
High Mobility Group Box 1 (HMGB1) (Non-oxidizable) (Active) proteinHMGB1 Origin: Human, Mouse, Rat Host: Escherichia coli (E. coli) Recombinant > 95 % Act, CA Active
High Mobility Group Box 1 (HMGB1) (Active) proteinHMGB1 Origin: Human, Mouse, Rat Host: Escherichia coli (E. coli) Recombinant > 95 % Act, CA Active
High Mobility Group Box 1 (HMGB1) (AA 1-90) protein (GST tag)HMGB1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
High Mobility Group Box 1 (HMGB1) (Active) protein (Fc Tag)HMGB1 Origin: Mouse Host: HEK-293 Cells Recombinant > 85 % as determined by SDS-PAGE Active
High Mobility Group Box 1 (HMGB1) (AA 1-215) protein (His tag)HMGB1 Origin: Human Host: Hi-5 Cells Recombinant > 90 % by SDS - PAGE SDS
High Mobility Group Box 1 (HMGB1) (AA 1-215) proteinHMGB1 Origin: Human Host: Baculovirus Recombinant > 90 % pure SDS
-
-
Restrictions
- For Research Use only
-
-
-
Format
- Lyophilized
-
Buffer
- 50 mM HEPES-Na pH 7.9, 500 mM NaCl, 0.5 mM DTT.
-
Handling Advice
- The product is resistant to repeated freezing and thawing.
-
Storage
- -20 °C
-
-
-
: "Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures." in: Nature medicine, Vol. 16, Issue 4, pp. 413-9, (2010) (PubMed).
-
: "Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures." in: Nature medicine, Vol. 16, Issue 4, pp. 413-9, (2010) (PubMed).
-
- HMGB1 (High Mobility Group Box 1 (HMGB1))
-
Alternative Name
- High-mobility group protein B1 (HMGB1)
-
Background
- BoxA is one of the highly conserved DNA binding domains of HMGB1 protein. It consists of 89 amino acids and has a calculated molecular mass of approximately 10.4 kDa. The sequence of BoxA is totally identical in human and mouse.
-
Molecular Weight
- approximately 10.4 kDa
-
Pathways
- p53 Signaling, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Toll-Like Receptors Cascades, Smooth Muscle Cell Migration, Inflammasome
Target
-
