HMGB1 Protein (BoxB Domain)
Quick Overview for HMGB1 Protein (BoxB Domain) (ABIN1176819)
Target
See all HMGB1 ProteinsProtein Type
Biological Activity
Origin
Source
Application
Purity
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Protein Characteristics
- BoxB Domain
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Sequence
- MARIDPNAPK RPPSAFFLFC SEYRPKIKGE HPGLSIGDVA KKLGEMWNNT AADDKQPYEK KAAKLKEKYE KDIAAYRAKG KPDAAKKGVV
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Characteristics
- BoxB recapitulates the cytokine activity of full length HMGB1 and efficiently activates macrophages to release tumor necrosis factor (TNF- ) and other proinflammatory cytokines (Li et al 2004). This product contains four amino acids (MARI) that have been added at the N terminus for the purpose of expression in bacteria. It contains only trace amounts of LPS (<0.4 ng/mg protein).
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Purification
- Purified
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Endotoxin Level
- The purified protein is free from LPS (Cambrex Limulus Amoebocyte Assay QCL-1000, <0.4 ng LPS per mg protein).
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High Mobility Group Box 1 (HMGB1) (AA 1-215) protein (GST tag)
HMGB1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
High Mobility Group Box 1 (HMGB1) (AA 1-215) protein (His tag,Biotin)HMGB1 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
High Mobility Group Box 1 (HMGB1) (Non-oxidizable) (Active) proteinHMGB1 Origin: Human, Mouse, Rat Host: Escherichia coli (E. coli) Recombinant > 95 % Act, CA Active
High Mobility Group Box 1 (HMGB1) (Active) proteinHMGB1 Origin: Human, Mouse, Rat Host: Escherichia coli (E. coli) Recombinant > 95 % Act, CA Active
High Mobility Group Box 1 (HMGB1) (AA 1-90) protein (GST tag)HMGB1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
High Mobility Group Box 1 (HMGB1) (AA 1-215) protein (His tag)HMGB1 Origin: Human Host: Baculovirus infected Insect Cells Recombinant > 90 % SDS
High Mobility Group Box 1 (HMGB1) (Active) protein (Fc Tag)HMGB1 Origin: Mouse Host: HEK-293 Cells Recombinant > 85 % as determined by SDS-PAGE Active
High Mobility Group Box 1 (HMGB1) (AA 1-215) proteinHMGB1 Origin: Human Host: Baculovirus Recombinant > 90 % pure SDS
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- 50 mM HEPES buffer pH 7.9, 500 mM NaCl, 0.5 mM DTT.
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Storage
- 4 °C/-20 °C
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Storage Comment
- The protein once resuspended can be stored frozen (-20°C).
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- HMGB1 (High Mobility Group Box 1 (HMGB1))
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Alternative Name
- High-mobility group protein B1 (HMGB1)
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Background
- BoxB is one of the DNA binding domains of HMGB1 protein. It consists of 90 amino acids and has a calculated molecular mass of approximately 10 kDa. The sequence of BoxB is totally identical in human and mouse.
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Molecular Weight
- approximately 10 kDa
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Pathways
- p53 Signaling, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Toll-Like Receptors Cascades, Smooth Muscle Cell Migration, Inflammasome
Target
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