RBP4 Protein (AA 19-201) (DYKDDDDK Tag)

Catalog No. ABIN1344327

This Recombinant RBP4 protein is expressed in HEK-293 Cells and has been mentioned in 1 publication.

Quick Overview for RBP4 Protein (AA 19-201) (DYKDDDDK Tag) (ABIN1344327)

Target: RBP4 (Retinol Binding Protein 4, Plasma (RBP4))

Protein Type: Recombinant

Origin: Rat

Source: HEK-293 Cells

Application: SDS-PAGE (SDS)

Purity: >90 % (SDS-PAGE)

Product Details

Protein Characteristics: AA 19-201

Purification tag / Conjugate: This RBP4 protein is labelled with DYKDDDDK Tag.

Purpose: RBP4 (rat) (rec.)

Cross-Reactivity: Rat

Characteristics: Rat RBP4 (aa 19-201) is fused at the N-terminus to a FLAG®-tag.

Sterility: Sterile filtered

Endotoxin Level: <0.1EU/μg purified protein (LAL test).

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.2μm-filtered solution in PBS, pH 7.2.

Handling Advice: After opening, prepare aliquots and store at -20 °C. Avoid freeze/thaw cycles. For maximum product recovery after thawing, centrifuge the vial before opening the cap.

Storage: 4 °C,-20 °C

Storage Comment:

Short Term Storage: +4°C

Long Term Storage: -20°C

Use & Stability: Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

Expiry Date: 6 months

References

Casillas-Ramírez, Alfany-Fernández, Massip-Salcedo, Juan, Planas, Serafín, Pallàs, Rimola, Rodés, Peralta: "Retinol-binding protein 4 and peroxisome proliferator-activated receptor-? in steatotic liver transplantation." in: The Journal of pharmacology and experimental therapeutics, Vol. 338, Issue 1, pp. 143-53, (2011) (PubMed).

Target Details

Target: RBP4 (Retinol Binding Protein 4, Plasma (RBP4))

Alternative Name: RBP4

Background:

Retinol Binding Protein 4

Retinol binding protein 4 (RBP4, RBP) is a 21 kDa secreted protein, a member of the lipocalin family and is known as the primary transporter of retinol (vitamin A) to tissues. A recent report revealed RBP4 as an adipokine linking glucose transporter 4 (GLUT4) suppression in adipose tissue to insulin. Elevated human and mouse serum RBP4 levels are associated with insulin resistance and its severity, obesity, and certain components of metabolic syndrome. Furthermore, human serum RBP4 levels are closely related to renal function.

Molecular Weight: ~23kDa (SDS-PAGE)

UniProt: P04916

Pathways: Regulatory RNA Pathways, Positive Regulation of Peptide Hormone Secretion, Carbohydrate Homeostasis, Production of Molecular Mediator of Immune Response