OB Cadherin Protein (AA 23-617) (His tag)

Catalog No. ABIN1691423

This Recombinant OB Cadherin protein is expressed in Human Cells.

Quick Overview for OB Cadherin Protein (AA 23-617) (His tag) (ABIN1691423)

Target: OB Cadherin (CDH11) (Cadherin 11 (CDH11))

Protein Type: Recombinant

Origin: Human

Source: Human Cells

Purity: > 95 % as determined by reducing SDS-PAGE.

Product Details

Protein Characteristics: AA 23-617

Purification tag / Conjugate: This OB Cadherin protein is labelled with His tag.

Purpose: Recombinant Human Cadherin-11/OB-Cadherin/CDH11 (C-6His)

Sequence: FAPERRGHLR PSFHGHHEKG KEGQVLQRSK RGWVWNQFFV IEEYTGPDPV LVGRLHSDID SGDGNIKYIL SGEGAGTIFV IDDKSGNIHA TKTLDREERA QYTLMAQAVD RDTNRPLEPP SEFIVKVQDI NDNPPEFLHE TYHANVPERS NVGTSVIQVT ASDADDPTYG NSAKLVYSIL EGQPYFSVEA QTGIIRTALP NMDREAKEEY HVVIQAKDMG GHMGGLSGTT KVMITLTDVN DNPPKFPQSV YQMSVSEAAV PGEEVGRVKA KDPDIGENGL VTYNIVDGDG MESFEITTDY ETQEGVIKLK KPVDFETKRA YSLKVEAANV HIDPKFISNG PFKDTVTVKI AVEDADEPPM FLAPSYIHEV QENAAAGTVV GRVHAKDPDA ANSPIRYSID RHTDLDRFFT INPEDGFIKT TKPLDREETA WLNITVFAAE IHNRHQEAKV PVAIRVLDVN DNAPKFAAPY EGFICESDQT KPLSNQPIVT ISADDKDDTA NGPRFIFSLP PEIIHNPNFT VRDNRDNTAG VYARRGGFSR QKQDLYLLPI VISDGGIPPM SSTNTLTIKV CGCDVNGALL SCNAEAYILN AGLSTVDHHH HHH

Characteristics:

Recombinant Human Cadherin-11/OB-Cadherin/CDH11 (C-6His)

Sterility: 0.2 μm filtered

Endotoxin Level: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.

Handling Advice: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Storage: 4 °C/-20 °C/-80 °C

Storage Comment: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: OB Cadherin (CDH11) (Cadherin 11 (CDH11))

Alternative Name: CDH11

Background: Recombinant Human Cadherin 11 Type 2 OB-Cadherin (Osteoblast)/CDH11 is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (Phe23-Thr617) of Human CDH11 fused with a polyhistidine tag at the C-terminus.
Cadherin-11 is a type II classical cadherin member of the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Cadherins interact with themselves in a homophilic manner in connecting cells, and thus contribute to the sorting of heterogeneous cell types. Cadherin-11 contains five cadherin domains and is mainly expressed in the brain. Mature cadherin proteins consists of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small highly conserved C-terminal cytoplasmic domain. It is shown that Cadherin-11 is a viable molecular target for therapeutic intervention in Glioblastoma multiforme.

Molecular Weight: 66.63 kDa

UniProt: Q96CZ9