Amphiregulin Protein (AREG) (AA 101-198)
Quick Overview for Amphiregulin Protein (AREG) (AA 101-198) (ABIN1692247)
Target
See all Amphiregulin (AREG) ProteinsProtein Type
Origin
Source
Purity
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Protein Characteristics
- AA 101-198
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Purpose
- Recombinant Human Amphiregulin/AREG
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Sequence
- MSVRVEQVVK PPQNKTESEN TSDKPKRKKK GGKNGKNRRN RKKKNPCNAE FQNFCIHGEC KYIEHLEAVT CKCQQEYFGE RCGEKSMKTH SMIDSSLSK
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Characteristics
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Recombinant Human Amphiregulin/AREG
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Sterility
- 0.2 μm filtered
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Endotoxin Level
- Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
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Amphiregulin (AREG) (Active) protein
AREG Origin: Human Host: Escherichia coli (E. coli) Recombinant >95 % as determined by SDS-PAGE Func Active
Amphiregulin (AREG) (AA 101-187) protein (Fc Tag)AREG Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Amphiregulin (AREG) (AA 100-248) protein (Fc Tag)AREG Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Amphiregulin (AREG) (AA 101-198) protein (His tag)AREG Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Amphiregulin (AREG) (AA 1-252) protein (GST tag)AREG Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Amphiregulin (AREG) (AA 20-187) protein (Fc Tag)AREG Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
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It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles. -
Buffer
- Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.
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Handling Advice
- Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
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Storage
- 4 °C/-20 °C/-80 °C
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Storage Comment
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Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Amphiregulin (AREG)
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Alternative Name
- Amphiregulin/AREG
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Background
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Recombinant Human Amphiregulin/AREG is produced with our E. coli expression system. The target protein is expressed with sequence (Ser101-Lys198) of Human AREG.
Amphiregulin (AREG) is a single-pass membrane protein with 252 AAs. AREG belongs to the amphiregulin family, which contains 1 EGF-like domain. AREG is expressed in a variety of tissues including ovary, placenta, lung, kidney, stomach, colon, and breast. It is related to Epidermal Growth Factor (EGF) and Transforming Growth Factor α (TGF-α). As an EGF-related growth factor, AREG interacts with the EGF/TGF-α receptor to promote the growth of normal epithelial cells and inhibits the growth of certain aggressive carcinoma cell lines. AREG may also play a protective role in Bleomycin-Induced Pneumopathy. -
Molecular Weight
- 11.4 kDa
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UniProt
- P15514
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Pathways
- RTK Signaling, EGFR Signaling Pathway
Target
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