Complement C4 Protein

Catalog No. ABIN1880330

This Native Complement C4 protein is produced in Human.

Quick Overview for Complement C4 Protein (ABIN1880330)

Target: Complement C4 (C4) (Complement 4 (C4))

Protein Type: Native

Biological Activity: Active

Origin: Human

Source: Human

Application: ELISA

Purity: >90 % by SDS-PAGE

Product Details

Purification: Purified

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 10 mM PBS ( pH 7.4).

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Shipat 4°C.Upon receipt, aliquot and store at -20°C or -80°C for long term. Avoid repeated freeze and thaw cycles.

Target Details

Target: Complement C4 (C4) (Complement 4 (C4))

Alternative Name: Complement C4

Background:

Synonyms: Complement C4-A, Acidic complement C4, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2, C4A, CO4, CPAMD2

Description: Purified human Complement C4 protein.

Background: Complement C4encodes the basic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gammachains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. In addition, this gene exists as a long form and a short form due to the presence or absence of a 6.4 kb endogenous HERV-K retrovirus in intron 9.

Pathways: Complement System