Interferon gamma Protein (IFNG)
Quick Overview for Interferon gamma Protein (IFNG) (ABIN2018000)
Target
See all Interferon gamma (IFNG) ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Characteristics
- ED50 < 2 ng/mL, measured in a cytotoxicity assay using HT-29 cells, corresponding to a specific activity of > 5x10^5 units/mg.
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Endotoxin Level
- < 0.2 EU/μg, determined by LAL method.
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Interferon gamma (IFNG) (AA 24-161) (Active) protein (Biotin,His-Avi Tag)
IFNG Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Interferon gamma (IFNG) (AA 24-161) (Active) protein (His-Avi Tag)IFNG Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Interferon gamma (IFNG) (Active) proteinIFNG Origin: Rat Host: Escherichia coli (E. coli) Recombinant >95 % as determined by SDS-PAGE Func Active
Interferon gamma (IFNG) (AA 23-155) (Active) proteinIFNG Origin: Mouse Host: Escherichia coli (E. coli) Recombinant > 95 % as analyzed by reducing SDS-PAGE. Active
Interferon gamma (IFNG) (AA 1-166) protein (GST tag)IFNG Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Interferon gamma (IFNG) (AA 24-166) proteinIFNG Origin: Dog Host: Escherichia coli (E. coli) Recombinant > 95 % SDS
Interferon gamma (IFNG) (AA 24-161) (Active) proteinIFNG Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % SDS, AcA Active
Interferon gamma (IFNG) (AA 24-161) (Active) protein (His tag)IFNG Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % SDS, AcA Active
Interferon gamma (IFNG) (AA 24-167) protein (His tag)IFNG Origin: Cat Host: Escherichia coli (E. coli) Recombinant > 95 % SDS
Interferon gamma (IFNG) (Active) protein (Fc Tag)IFNG Origin: Rat Host: HEK-293 Cells Recombinant > 92 % as determined by SDS-PAGE Active
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Reconstituted in ddH2O or PBS at 100 μg/mL.
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Buffer
- Lyophilized after extensive dialysis against PBS.
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Storage
- -80 °C
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Storage Comment
- Lyophilized recombinant Human Interferon gamma (IFN-gamma) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, rh IFN-gamma should be stable up to 1 week at 4 °C or up to 2 months at -20 °C.
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Expiry Date
- 6 months
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- Interferon gamma (IFNG)
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Alternative Name
- Interferon-gamma (IFN-Gamma)
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Background
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Human Interferon gamma (hIFN-gamma) is amacrophage-activating factor and the lone member of Interferon type II. The active form of IFN-gamma is an antiparallel dimer that interacts with the receptor IFN-gamma R1 and sets off IFN-gamma/JAK/STAT pathway. IFN-gamma signaling does diverse biological functions primarily related to host defense and immune regulation, including antiviral and antibacterial defense, apoptosis, inflammation, and innate and acquired immunity. While IFN-gamma induced inflammatory cascade summons a variety of immune-related cell types, such as macrophages, natural killer (NK) cells and cytotoxic T lymphocytes (CTLs), IFN-gamma is also implicated in resistance to NK cell and CTL responses and in immune escape in a variety of cancers.
Synonyms: Immune Interferon, type II interferon, T cell interferon, MAF -
Molecular Weight
- 15-25 kDa, observed by non-reducing SDS-PAGE.
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Pathways
- Interferon-gamma Pathway, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus, Autophagy
Target
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