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IL4 Receptor Protein (AA 24-232)

IL4R Origin: Human Host: HEK-293T Cells Recombinant > 95 % as analyzed by SDS-PAGE and HPLC. Active
Catalog No. ABIN2018120
  • Target See all IL4 Receptor (IL4R) Proteins
    IL4 Receptor (IL4R) (Interleukin 4 Receptor (IL4R))
    Protein Type
    Recombinant
    Biological Activity
    Active
    Protein Characteristics
    AA 24-232
    Origin
    • 22
    • 9
    • 7
    • 5
    • 4
    • 1
    Human
    Source
    • 24
    • 6
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    HEK-293T Cells
    Characteristics
    ED50 < 70 ng/mL, measured in a neutralization assay using TF-1 cells in the presence of 0.5 ng/mL h-IL-4.
    Purity
    > 95 % as analyzed by SDS-PAGE and HPLC.
    Endotoxin Level
    < 0.2 EU/μg, determined by LAL method.
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    Discover our top product IL4R Protein
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Reconstituted in ddH2O or PBS at 100 μg/mL.
    Buffer
    Lyophilized after extensive dialysis against PBS.
    Storage
    -80 °C
    Storage Comment
    Lyophilized recombinant Human Interleukin-4 Receptor remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, Human Interleukin-4 Receptor should be stable up to 1 week at 4 °C or up to 2 months at -20 °C.
    Expiry Date
    6 months
  • Target
    IL4 Receptor (IL4R) (Interleukin 4 Receptor (IL4R))
    Alternative Name
    Interleukin-4 Receptor (IL4R Products)
    Background
    Interleukin-4 Receptor, also known as IL-4RA and CD124, is a transmembrane glycoprotein belonging to the class I receptor family. It is highly expressed by activated T-cells. IL-4RA couples with gamma chain to form the type I receptor for IL-4. The extracellular domain of IL-4RA binds to IL-4 and antagonizes its activity. IL-4RA plays an important role in Th2 cell differentiation, Ig class switching and alternative macrophage activation. It has also been implicated in allergic inflammation, tumor progression and atherogenesis.
    Synonyms: IL-4R, IL-4RA, CD124
    Molecular Weight
    40-45 kDa, observed by reducing SDS-PAGE.
    UniProt
    P24394
    Pathways
    JAK-STAT Signaling, Positive Regulation of Immune Effector Process
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