IL4 Receptor Protein (AA 24-232)
Quick Overview for IL4 Receptor Protein (AA 24-232) (ABIN2018120)
Target
See all IL4 Receptor (IL4R) ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Protein Characteristics
- AA 24-232
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Characteristics
- ED50 < 70 ng/mL, measured in a neutralization assay using TF-1 cells in the presence of 0.5 ng/mL h-IL-4.
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Endotoxin Level
- < 0.2 EU/μg, determined by LAL method.
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Interleukin 4 Receptor (IL4R) (AA 24-232) protein (Fc Tag)
IL4R Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 4 Receptor (IL4R) (AA 26-232) protein (His tag)IL4R Origin: Cynomolgus Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 4 Receptor (IL4R) (AA 24-232) protein (His tag)IL4R Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 4 Receptor (IL4R) (AA 26-232) protein (Fc Tag)IL4R Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Interleukin 4 Receptor (IL4R) (AA 26-232) protein (mFc Tag)IL4R Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Interleukin 4 Receptor (IL4R) (AA 26-232) protein (His tag)IL4R Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Interleukin 4 Receptor (IL4R) (AA 26-232) (Active) protein (Fc Tag)IL4R Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Interleukin 4 Receptor (IL4R) protein (His tag)IL4R Origin: Mouse Host: Human Cells Recombinant >95 % as determined by reducing SDS-PAGE.
Interleukin 4 Receptor (IL4R) (Active) protein (His tag)IL4R Origin: Cynomolgus Host: Human Cells Recombinant > 95 % as determined by reducing SDS-PAGE. Active
Interleukin 4 Receptor (IL4R) protein (Fc Tag)IL4R Origin: Mouse Host: Human Cells Recombinant > 90 % as determined by reducing SDS-PAGE.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Reconstituted in ddH2O or PBS at 100 μg/mL.
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Buffer
- Lyophilized after extensive dialysis against PBS.
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Storage
- -80 °C
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Storage Comment
- Lyophilized recombinant Human Interleukin-4 Receptor remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, Human Interleukin-4 Receptor should be stable up to 1 week at 4 °C or up to 2 months at -20 °C.
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Expiry Date
- 6 months
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- IL4 Receptor (IL4R) (Interleukin 4 Receptor (IL4R))
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Alternative Name
- Interleukin-4 Receptor
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Background
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Interleukin-4 Receptor, also known as IL-4RA and CD124, is a transmembrane glycoprotein belonging to the class I receptor family. It is highly expressed by activated T-cells. IL-4RA couples with gamma chain to form the type I receptor for IL-4. The extracellular domain of IL-4RA binds to IL-4 and antagonizes its activity. IL-4RA plays an important role in Th2 cell differentiation, Ig class switching and alternative macrophage activation. It has also been implicated in allergic inflammation, tumor progression and atherogenesis.
Synonyms: IL-4R, IL-4RA, CD124 -
Molecular Weight
- 40-45 kDa, observed by reducing SDS-PAGE.
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UniProt
- P24394
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Pathways
- JAK-STAT Signaling, Positive Regulation of Immune Effector Process
Target
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