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IL-5 Protein (AA 20-132)

IL5 Origin: Rat Host: Escherichia coli (E. coli) Recombinant > 95 % by SDS-PAGE analysis. Active
Catalog No. ABIN2018127
  • Target See all IL-5 (IL5) Proteins
    IL-5 (IL5) (Interleukin 5 (IL5))
    Protein Type
    Recombinant
    Biological Activity
    Active
    Protein Characteristics
    AA 20-132
    Origin
    • 20
    • 15
    • 6
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Rat
    Source
    • 26
    • 17
    • 9
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    Escherichia coli (E. coli)
    Characteristics
    ED50 < 0.4 ng/mL, measured by a cell proliferation assay using TF-1 Cells, corresponding to a specific activity of > 2.5x 10^6 units/mg.
    Purity
    > 95 % by SDS-PAGE analysis.
    Endotoxin Level
    < 0.2 EU/μg, determined by LAL method.
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  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Reconstituted in ddH2O at 100 μg/mL.
    Buffer
    Lyophilized after extensive dialysis against 20 mM Tris, pH 8.5.
    Storage
    -80 °C
    Storage Comment
    Lyophilized recombinant rat Interleukin-5 (rrIL-5) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, rrIL-5 should be stable up to 2 weeks at 4 °C or up to 3 months at -20 °C.
    Expiry Date
    6 months
  • Target
    IL-5 (IL5) (Interleukin 5 (IL5))
    Alternative Name
    Interleukin-5 (IL-5) (IL5 Products)
    Synonyms
    EDF Protein, IL-5 Protein, TRF Protein, Il-5 Protein, IL5 Protein, interleukin 5 Protein, IL5 Protein, Il5 Protein
    Background
    Interleukin-5 (IL-5), produced by mast cells, T cells and eosinophils, is responsible for the activities attributed to eosinophil differentiating factor, B cell growth factor II and T cell-replacing factor (TRF). It can increase production and mobilization of eosinophils and CD34+ progenitors from the bone marrow. IL-5 plays an important role in inducing cell-mediated immunity against parasitic infections and certain tumors. IL-5 also promotes differentiation of basophils and primes them for histamine and leukotriene release.Recombinant rat Interleukin-5 (rrIL-5) produced in E. coli is a disulfide-linked homodimer containing two non-glycosylated polypeptide chains of 113 amino acids each. A fully biologically active molecule, rrIL-5 has a molecular mass of 26.0 kDa analyzed by non-reducing SDS-PAGE.
    Synonyms: EDF, BCDFII, TRF
    Molecular Weight
    26.0 kDa, observed by non-reducing SDS-PAGE.
    UniProt
    Q08125
    Pathways
    JAK-STAT Signaling, Positive Regulation of Peptide Hormone Secretion, Production of Molecular Mediator of Immune Response, Feeding Behaviour
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