IL-6 Protein (AA 29-212)
Quick Overview for IL-6 Protein (AA 29-212) (ABIN2018139)
Target
See all IL-6 (IL6) ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Protein Characteristics
- AA 29-212
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Characteristics
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ED50 <0.1 ng/mL, measured by the dose-dependent stimulation of the proliferation of IL-6 dependent murine 7TD1 cells, corresponding to a specific activity of > 1 x 10^7 units/mg.
AA 29-212, expressed with an N-terminal Met. -
Endotoxin Level
- < 0.2 EU/μg, determined by LAL method.
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Interleukin 6 (IL6) (AA 30-212) protein (mFc-His Tag)
IL6 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ELISA, FACS
Interleukin 6 (IL6) (AA 30-212) proteinIL6 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by Tris-Bis PAGE,> 90 % as determined by HPLC
Interleukin 6 (IL6) (AA 28-212) protein (His tag)IL6 Origin: Cynomolgus Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 6 (IL6) (AA 25-211) (Active) protein (His tag)IL6 Origin: Mouse Host: CHO Cells Recombinant > 95 % as analyzed by SDS-PAGE. Active
Interleukin 6 (IL6) (AA 30-212) (Active) proteinIL6 Origin: Human Host: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Interleukin 6 (IL6) (AA 30-212) (Active) protein (His tag)IL6 Origin: Human Host: HEK-293 Cells > 97 % AcA, CC Active
Interleukin 6 (IL6) (AA 25-211) protein (Fc Tag)IL6 Origin: Mouse Host: Mammalian Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Interleukin 6 (IL6) (AA 25-211) protein (His tag)IL6 Origin: Rat Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Interleukin 6 (IL6) (AA 47-241) protein (His tag)IL6 Origin: Chicken Host: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Reconstituted in ddH2O at 100 μg/mL.
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Buffer
- Lyophilized after extensive dialysis against 1xPBS.
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Storage
- -80 °C
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Storage Comment
- Lyophilized recombinant human Interleukin-6 (rhIL-6) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, rhIL-6 should be stable up to 2 weeks at 4 °C or up to 3 months at -20 °C.
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Expiry Date
- 6 months
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- IL-6 (IL6) (Interleukin 6 (IL6))
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Alternative Name
- Interleukin-6 (IL-6)
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Background
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Interleukin-6 (IL-6, also known as IFN-beta2) is a pleiotropic cytokine that plays important roles in acute phase reactions, inflammation, hematopoiesis, bone metabolism, and cancer progression. IL-6 is secreted by T cells and macrophages to stimulate immune response. IL-6 is responsible for stimulating acute phase protein synthesis, as well as the production of neutrophils in the bone marrow. It supports the growth of B cells and is antagonistic to regulatory T cells.Recombinant human Interleukin-6 (rhIL-6) produced in E. coli is a single non-glycosylated polypeptide chain containing 185 amino acids. A fully biologically active molecule, rhIL-6 has a molecular mass of 20.9 kDa analyzed by reducing SDS-PAGE.
Synonyms: 26 kDa protein, IFN-beta2, B cell differentiation factor (BCDF), BSF-2, HPGF, HSF, MGI-2 -
Molecular Weight
- 20.9 kDa, observed by reducing SDS-PAGE.
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UniProt
- Q75MH2
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Pathways
- TLR Signaling, Hormone Transport, Negative Regulation of Hormone Secretion, Myometrial Relaxation and Contraction, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Regulation of Carbohydrate Metabolic Process, Autophagy, Cell RedoxHomeostasis, Cancer Immune Checkpoints, Inflammasome
Target
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