CCL2 Protein (AA 24-96)
Quick Overview for CCL2 Protein (AA 24-96) (ABIN2018228)
Target
See all CCL2 ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Protein Characteristics
- AA 24-96
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Characteristics
- The EC50 value of mouse MCP-1/CCL2 on Ca2+ mobilization assay in CHO-K1/Ga15/mCCR2 cells (human Ga15 and mouse CCR2 stably expressed in CHO-K1 cells) is less than 0.3 μg/mL.
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Endotoxin Level
- < 0.2 EU/μg, determined by LAL method.
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Chemokine (C-C Motif) Ligand 2 (CCL2) (AA 24-99) (Active) protein (Biotin,His-Avi Tag)
CCL2 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Chemokine (C-C Motif) Ligand 2 (CCL2) (AA 24-99) (Active) protein (His-Avi Tag)CCL2 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Chemokine (C-C Motif) Ligand 2 (CCL2) (AA 24-99) (Active) protein (His tag)CCL2 Origin: Cynomolgus Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Chemokine (C-C Motif) Ligand 2 (CCL2) (AA 24-99) (Active) protein (Biotin)CCL2 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 97 % by SDS PAGE CMA, FACS Active
Chemokine (C-C Motif) Ligand 2 (CCL2) (AA 24-148) protein (His-IF2DI Tag)CCL2 Origin: Mouse Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Chemokine (C-C Motif) Ligand 2 (CCL2) (AA 24-99) (Active) protein (His tag)CCL2 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA Active
Chemokine (C-C Motif) Ligand 2 (CCL2) (AA 24-96) (Active) protein (His tag)CCL2 Origin: Mouse Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA Active
Chemokine (C-C Motif) Ligand 2 (CCL2) (AA 24-148) protein (His-IF2DI Tag)CCL2 Origin: Rat Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Chemokine (C-C Motif) Ligand 2 (CCL2) (AA 1-99) protein (GST tag)CCL2 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Chemokine (C-C Motif) Ligand 2 (CCL2) protein (His tag)CCL2 Origin: Mouse Host: Human Cells Recombinant > 95 % as determined by SDS-PAGE
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Reconstituted in ddH2O or PBS at 100 μg/mL.
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Buffer
- Lyophilized after extensive dialysis against PBS.
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Storage
- -80 °C
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Storage Comment
- Lyophilized recombinant Mouse MCP-1/CCL2 remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, Mouse MCP-1/CCL2 should be stable up to 1 week at 4 °C or up to 3 months at -20 °C.
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Expiry Date
- 6 months
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- CCL2 (Chemokine (C-C Motif) Ligand 2 (CCL2))
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Alternative Name
- MCP-1/CCL2
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Background
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Chemokine (C-C motif) ligand 2 (CCL2) is also referred to as monocyte chemotactic protein 1 (MCP1) and small inducible cytokine A2. CCL2 is a small cytokine that belongs to the CC chemokine family. CCL2 recruits monocytes, memory T cells, and dendritic cells to the sites of inflammation produced by either tissue injury or infection. CCL2 is implicated in the pathogeneses of several types of disease characterized by monocytic infiltrates, such as psoriasis, rheumatoid arthritis and atherosclerosis. CCL2 is anchored in the plasma membrane of endothelial cells by glycosaminoglycan side chains of proteoglycans. CCL2 is primarily secreted by monocytes, macrophages and dendritic cells. CCL2 can signal through the CCR2 receptor.Recombinant mouse MCP-1/CCL2 produced in HEK293 cells is a polypeptide chain containing 73 amino acids. A fully biologically active molecule, r mMCP-1/CCL2 has a molecular mass of 8 kDa analyzed by reducing SDS-PAGE.
Synonyms: MCP-1, MCAF, JE, Monocyte Chemotactic Protein-1 (MCP-1), CCL2 -
Molecular Weight
- 8 kDa, observed by reducing SDS-PAGE.
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UniProt
- Q5SVU3
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Pathways
- Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, ER-Nucleus Signaling, Unfolded Protein Response, The Global Phosphorylation Landscape of SARS-CoV-2 Infection
Target
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