Oncostatin M Protein (OSM) (AA 24-206)

Catalog No. ABIN2018306

This Recombinant Oncostatin M protein is expressed in HEK-293T Cells.

Quick Overview for Oncostatin M Protein (OSM) (AA 24-206) (ABIN2018306)

Target: Oncostatin M (OSM)

Protein Type: Recombinant

Biological Activity: Active

Origin: Mouse

Source: HEK-293T Cells

Purity: > 95 % as analyzed by SDS-PAGE and HPLC.

Product Details

Protein Characteristics: AA 24-206

Characteristics: ED50 < 0.4 ng/mL, measured in a cell proliferation assay using NIH-3T3 cells.

Endotoxin Level: < 0.2 EU/μg, determined by LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Reconstituted in ddH2O or PBS at 100 μg/mL.

Buffer: Lyophilized after extensive dialysis against PBS.

Storage: -80 °C

Storage Comment: Lyophilized recombinant Murine Oncostatin-M remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, Murine Oncostatin-M should be stable up to 1 week at 4 °C or up to 2 months at -20 °C.

Expiry Date: 6 months

Target Details

Target: Oncostatin M (OSM)

Alternative Name: Oncostatin-M (OSM)

Background: Oncostatin-M, also known as OSM, is a growth regulator belonging to the interleukin-6 group of cytokines. It is expressed mainly by monocytes, activated T cells and Kaposi's sarcoma cells. OSM signals through two types of receptors, one is composed of gp130 and LIFR, and the other is composed of gp130 and OSMR. OSM regulates IL-6, G-CSF and GM-CSF production, and thus is involved in hematopoiesis, neurogenesis and osteogenesis. OSM displays both stimulatory and inhibitory effects, so its categorization as pro-inflammatory or anti-inflammatory cytokine is still controversial.
Synonyms: OSM

Molecular Weight: 10-40 kDa, observed by reducing SDS-PAGE.

UniProt: P53347

Pathways: JAK-STAT Signaling, Negative Regulation of Hormone Secretion