TGFA Protein (AA 40-89)
Quick Overview for TGFA Protein (AA 40-89) (ABIN2018416)
Target
See all TGFA ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Protein Characteristics
- AA 40-89
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Characteristics
- ED50 < 0.4 ng/mL, measured in a cell proliferation assay using 3T3 cells.
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Endotoxin Level
- < 0.2 EU/μg, determined by LAL method.
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Transforming Growth Factor, alpha (TGFA) (AA 40-89) protein (Fc Tag)
TGFA Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Transforming Growth Factor, alpha (TGFA) (AA 39-88) protein (Fc Tag)TGFA Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Transforming Growth Factor, alpha (TGFA) (AA 40-89) protein (His tag)TGFA Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Transforming Growth Factor, alpha (TGFA) (AA 1-159) protein (GST tag)TGFA Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Reconstituted in ddH2O or PBS at 100 μg/mL.
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Buffer
- Lyophilized after extensive dialysis against PBS.
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Storage
- -80 °C
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Storage Comment
- Lyophilized recombinant Human TGF-alpha remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, Human TGF-alpha Receptor should be stable up to 1 week at 4 °C or up to 2 months at -20 °C.
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Expiry Date
- 6 months
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- TGFA (Transforming Growth Factor, alpha (TGFA))
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Alternative Name
- Transforming Growth Factor-alpha (TGF-Alpha)
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Background
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Protransforming Growth Factor-alpha (TGF-alpha), also known as sarcoma growth factor, TGF-type I and ETGF, is a member of the EGF family of cytokines. It is expressed in monocytes, brain cells, keratinocytes and various tumor cells. ProTGF-alpha signals through EGFR and acts synergistically with TGF-beta to promote the proliferation of a wide range of epidermal and epithelial cells. It may function as either a membrane-bound ligand or a soluble ligand. Membrane-bound proTGF-alpha plays a role in cell-cell adhesion and juxtacrine stimulation of adjacent cells. The soluble form of the cytokine is released from the membrane-bound form by proteolytic cleavage and acts as a mitogen for cell proliferation.
Synonyms: Transforming Growth Factor-alpha, Sacroma growth factor, TGF-type I, ETGF -
Molecular Weight
- 8-10 kDa, observed by reducing SDS-PAGE.
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UniProt
- P01135
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Pathways
- NF-kappaB Signaling, RTK Signaling, EGFR Signaling Pathway
Target
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