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NRG1-beta 1 Protein (AA 176-246)

NRG1-beta 1 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by reducing SDS-PAGE.
Catalog No. ABIN2115486
  • Target See all NRG1-beta 1 products
    NRG1-beta 1 (Neuregulin-1 beta 1 (NRG1-beta 1))
    Protein Type
    Recombinant
    Protein Characteristics
    AA 176-246
    Origin
    Human
    Source
    • 3
    • 1
    Escherichia coli (E. coli)
    Purpose
    Recombinant Human Pro-Neuregulin-1/NRG1-β1/HRG1-β1 (Thr176-Lys246)
    Sequence
    TSHLVKCAEK EKTFCVNGGE CFMVKDLSNP SRYLCKCPNE FTGDRCQNYV MASFYKHLGI EFMEAEELYQ K
    Characteristics
    Recombinant Human Pro-neuregulin-1 is produced by our E. coli expression system. The target protein is expressed with sequence (Thr176-Lys246) of Human NRG1.
    Purity
    > 95 % as determined by reducing SDS-PAGE.
    Sterility
    0.2 μm filtered
    Endotoxin Level
    Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    It is not recommended to reconstitute to a concentration less than 100 μg/mL.
    Dissolve the lyophilized protein in ddH2O.
    Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
    Buffer
    Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.
    Handling Advice
    Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
    Storage
    4 °C/-20 °C/-80 °C
    Storage Comment
    Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
    Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
    Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target
    NRG1-beta 1 (Neuregulin-1 beta 1 (NRG1-beta 1))
    Abstract
    NRG1-beta 1 Products
    Background
    Neuregulin-1 (heregulin-1,NRG1) is a member of neuregulin family, which is comprised of four genes that encode a large number of secreted or membrane-bound isoforms. All family members share an EGF-like domain that interacts with the ErbB family of tyrosine kinase receptors. NRG1 isoforms can be classified into type I, type II and type III isoforms. NRG1 directs ligand for ERBB3 and ERBB4 tyrosine kinase receptors, concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. NRG proteins show distinct spatial and temporal expression patterns and play important roles during development of both the nervous system and the heart.
    Synonyms: Pro-neuregulin-1,Neuregulin-1 beta 1,NRG1-beta 1,HRG1-beta 1, EGF,NRG1, GGF, HGL, HRGA, NDF, SMDF,
    Molecular Weight
    8.2 kDa
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