NRG1-beta 1 Protein (AA 2-246) (Fc Tag)
NRG1-beta 1
Origin: Human
Host: HEK-293 Cells
Recombinant
>90 % as determined by SDS-PAGE.
Active
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- Target See all NRG1-beta 1 products
- NRG1-beta 1 (Neuregulin-1 beta 1 (NRG1-beta 1))
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- AA 2-246
- Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This NRG1-beta 1 protein is labelled with Fc Tag.
- Characteristics
- Human NRG1 Beta 1 Protein, Fc Tag
- Purity
- >90 % as determined by SDS-PAGE.
- Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- PBS, pH 7.4
- Storage
- -20 °C
-
- Target
- NRG1-beta 1 (Neuregulin-1 beta 1 (NRG1-beta 1))
- Alternative Name
- NRG1 Beta 1 (NRG1-beta 1 Products)
- Background
- NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. It is known that an extraordinary variety of different isoforms are produced from the NRG1 gene by alternative splicing. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF). They are tissue-specific and differ significantly in their structure. The HRG isoforms all contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains. GGF and GGF2 isoforms contain a kringle-like sequence plus Ig and EGF-like domains, and the SMDF isoform shares only the EGF-like domain with other isoforms. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through their displayed interaction with ERBB receptors, NRG1 isoforms induce the growth and differentiation of epithelial, neuronal, glial, and other types of cells.
- Molecular Weight
- 53.2 kDa
- NCBI Accession
- NP_039250
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