C5A Protein (AA 679-751)

Catalog No. ABIN2180666

This Recombinant C5A protein is produced in Escherichia coli (E. coli).

Quick Overview for C5A Protein (AA 679-751) (ABIN2180666)

Target: C5A (C5a) (Complement Component 5a (C5a))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Purity: >95 % as determined by SDS-PAGE.

Product Details

Protein Characteristics: AA 679-751

Sequence: AA 679-751

Characteristics: This protein carries no "tag". The protein has a calculated MW of 8.3 kDa. The protein migrates as 8.3 kDa under reducing (R) condition (SDS-PAGE).

Sterility: 0.22 μm filtered

Endotoxin Level: Less than 1.0 EU per μg by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: PBS, pH 7.4

Handling Advice: Please avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).

Target Details

Target: C5A (C5a) (Complement Component 5a (C5a))

Alternative Name: Complement Component C5a

Background: Human Complement Component C5a (C5a) is also known as C5,and is a protein fragment released from complement component C5.,is a potent chemotactic factor for human peripheral blood neutrophils and monocytes, and is believed to play an important role in a number of inflammatory conditions. There are several functions in the below: C5a is an anaphylatoxin, causing the release of histamine from mast cells, C5a is effective leukocyte chemoattractants, causing the accumulation of white blood cells, especially neutrophil granulocytes, at sites of complement activation, C5a activates white blood cells by increasing avidity for white blood cell integrins and upregulating the Lipoxygenase pathway for arachidonic acid metabolism, C5a is a powerful inflammatory mediator, and seems to be a key factor in the development of pathology of many inflammatory diseases involving the complement system, C5a modulates balance between activating versus inhibitory IgG Fc receptors on leukocytes, thereby enhancing autoimmune response.

Molecular Weight: 8.3 kDa

UniProt: P01031

Pathways: Complement System, Carbohydrate Homeostasis