ATG5 Protein (AA 1-275) (His tag)
Quick Overview for ATG5 Protein (AA 1-275) (His tag) (ABIN2468251)
Target
See all ATG5 ProteinsProtein Type
Origin
Source
Application
Purity
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Protein Characteristics
- AA 1-275
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Purification tag / Conjugate
- This ATG5 protein is labelled with His tag.
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ATG5 Autophagy Related 5 (ATG5) (AA 1-275) protein (His tag)
custom-made ATG5 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
ATG5 Autophagy Related 5 (ATG5) (AA 1-275) protein (His tag)custom-made ATG5 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
ATG5 Autophagy Related 5 (ATG5) (AA 138-275) protein (His-IF2DI Tag)ATG5 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. ELISA, WB
ATG5 Autophagy Related 5 (ATG5) (AA 1-275) protein (His-IF2DI Tag)ATG5 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. ELISA, WB
ATG5 Autophagy Related 5 (ATG5) (AA 1-275) protein (GST tag)ATG5 Origin: Human Host: Wheat germ Recombinant AP, AA, ELISA, WB
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Application Notes
- This recombinant protein can be used for WB, ELISA, MS and neutralization assays.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- 1X PBS containing 10 % glycerol
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Handling Advice
- Avoid freeze/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
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Storage
- -80 °C
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Storage Comment
- Store in working aliquots at -70 °C.
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- ATG5 (ATG5 Autophagy Related 5 (ATG5))
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Alternative Name
- ATG5
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Background
- Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components (1,2). This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1 (3). ATG5, another member of the autophagy protein family, forms a conjugate with ATG12 , this conjugate has a ubiquitin-protein ligase (E3)-like activity for protein lipidation in autophagy (4). This conjugate also associates with innate immune response proteins such as RIG-I and VISA (also known as IPS-1), inhibiting type I interferon production and permitting viral replication in host cells (5).
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Molecular Weight
- 34 kDa (Calculated)
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Gene ID
- 9474
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OMIM
- 10285391
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UniProt
- A9UGY9
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Pathways
- Activation of Innate immune Response, Production of Molecular Mediator of Immune Response, Autophagy
Target
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