ATG7 Protein (AA 450-698) (His tag)
Quick Overview for ATG7 Protein (AA 450-698) (His tag) (ABIN2468252)
Target
See all ATG7 ProteinsProtein Type
Origin
Source
Application
Purity
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Protein Characteristics
- AA 450-698
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Purification tag / Conjugate
- This ATG7 protein is labelled with His tag.
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ATG7 Autophagy Related 7 (ATG7) (AA 1-698) protein (His tag)
custom-made ATG7 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
ATG7 Autophagy Related 7 (ATG7) (AA 1-703) protein (GST tag)ATG7 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
ATG7 Autophagy Related 7 (ATG7) (AA 410-619) protein (His-IF2DI Tag)ATG7 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
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Application Notes
- This recombinant protein can be used for WB, ELISA, MS and neutralization assays.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- 1X PBS containing 10 % glycerol
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Handling Advice
- Avoid freeze/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
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Storage
- -80 °C
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Storage Comment
- Store in working aliquots at -70 °C.
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- ATG7 (ATG7 Autophagy Related 7 (ATG7))
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Alternative Name
- ATG7
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Background
- Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components (1,2). This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1 (3). Another member of the autophagy family of proteins is APG7 which was identified in yeast as a ubiquitin-E1-like enzyme , this function is conserved in the mammalian homolog (4). In mammalian cells, APG7 is essential for autophagy conjugation systems, autophagosome formation, starvation-induced bulk degradation of proteins and organelles (5). It has been suggested that caspase-8 may alter APG7 levels and thus the APG7 program of autophagic cell death (6).
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Molecular Weight
- 30 kDa (Calculated)
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Gene ID
- 74244
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OMIM
- 37589293
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UniProt
- Q9D906
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Pathways
- Response to Water Deprivation, Autophagy
Target
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