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alpha Defensin 1 Protein

DEFA1 Origin: Human Host: Escherichia coli (E. coli) Recombinant < 98 % by SDS-PAGE gel and HPLC analyses. Active
Catalog No. ABIN2468909
  • Target See all alpha Defensin 1 (DEFA1) Proteins
    alpha Defensin 1 (DEFA1) (Defensin, alpha 1 (DEFA1))
    Protein Type
    Recombinant
    Biological Activity
    Active
    Origin
    • 3
    • 2
    • 1
    • 1
    Human
    Source
    • 3
    • 2
    • 1
    • 1
    Escherichia coli (E. coli)
    Sequence
    ACYCRIPACI AGERRYGYCI YQGRLWAFCC
    Characteristics
    Determined by its ability to chemoattract immature dendritic cells using a concentration of 1.0 - 10.0 ng/mL.
    Purity
    < 98 % by SDS-PAGE gel and HPLC analyses.
    Endotoxin Level
    Endotoxin level is less than 0.1 ng per μg (1 EU/μg).
    Top Product
    Discover our top product DEFA1 Protein
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Handling Advice
    As with any protein, exposing NP-1 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
    Storage
    -20 °C
    Storage Comment
    The recombinant protein is stable for at least 2 years from date of receipt at -20 °C. Reconstituted NP-1 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20 °C.
    Expiry Date
    24 months
  • Target
    alpha Defensin 1 (DEFA1) (Defensin, alpha 1 (DEFA1))
    Alternative Name
    alpha Defensin-1 (DEFA1 Products)
    Synonyms
    DEF1 Protein, DEFA2 Protein, HNP-1 Protein, HP-1 Protein, HP1 Protein, MRS Protein, Defcr Protein, Defcr1 Protein, DEFA1 Protein, Defa Protein, Def Protein, GB19392 Protein, defensin alpha 1 Protein, defensin, alpha 1 Protein, defensin alpha 5 Protein, alpha-defensin 1A Protein, defensin 1 Protein, neutrophil defensin 1 Protein, DEFA1 Protein, Defa1 Protein, Defa5 Protein, MNP1A Protein, Def1 Protein, LOC107973256 Protein
    Background
    Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The α-defensins which include NP-1, NP-2 and NP-3, are distinguished from the beta-defensins by the pairing of their three disulfide bonds. In addition to antimicrobial activity, NP-1 exhibits chemotactic activity on dendritic cells. NP-1 is expressed as the C-terminal portion of an inactive precursor protein, which also contains a 19 amino acid N-terminal signal sequence and a 45 amino acid polypeptide. NP-1 contains a six-cysteine motif that forms three intra-molecular disulfide bonds. Recombinant human NP-1 is a 3.4 kDa protein containing 30 amino acid residues.
    Gene ID
    1667
    NCBI Accession
    NP_004075
    OMIM
    4758146
    UniProt
    P59665
    Pathways
    Cellular Response to Molecule of Bacterial Origin
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