Leptin Receptor Protein (LEPR) (Fc Tag)
Quick Overview for Leptin Receptor Protein (LEPR) (Fc Tag) (ABIN2566758)
Target
See all Leptin Receptor (LEPR) ProteinsProtein Type
Biological Activity
Origin
Source
Application
Purity
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Purification tag / Conjugate
- This Leptin Receptor protein is labelled with Fc Tag.
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Characteristics
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Measured by its ability to inhibit Leptin-dependent proliferation of BaF3 mouse pro-B cells transfected with rhLEPR-Fc. The ED50 for this effect is typically 0. 015-0. 13 μg/mL in the presence of 3 ng/mL rhLeptin.
Fusion tag: C-Fc Tag
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Leptin Receptor (LEPR) protein (mFc Tag)
LEPR Origin: Mouse Host: Human Cells Recombinant >95 % as determined by reducing SDS-PAGE.
Leptin Receptor (LEPR) protein (His tag)LEPR Origin: Mouse Host: Human Cells Recombinant >90 % as determined by reducing SDS-PAGE.
Leptin Receptor (LEPR) protein (Fc Tag)LEPR Origin: Mouse Host: Human Cells Recombinant >95 % as determined by reducing SDS-PAGE.
Leptin Receptor (LEPR) protein (Fc Tag)LEPR Origin: Human Host: Human Cells Recombinant >95 % as determined by reducing SDS-PAGE.
Leptin Receptor (LEPR) (AA 22-839) protein (His tag)LEPR Origin: Human Host: Mammalian Cells Recombinant The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
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Application Notes
- This recombinant protein can be used for WB. For research use only.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- PBS, pH 7.4
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Storage
- -80 °C,-20 °C
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Storage Comment
- Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
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- Leptin Receptor (LEPR)
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Alternative Name
- LEPR
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Background
- Leptin receptor (LEPR) is also known as LEP-R, cluster of differentiation 295 (CD295), OB-R and B219, is a single-transmembrane-domain receptor of the gp130 family of cytokine receptors. Leptin receptor exists as homodimer and binds Leptin with high affinity, thus mediates the biological function of the adipocyte-specific hormone Leptin. LEPR is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this protein have been associated with obesity and pituitary dysfunction. Interaction of leptin and leptin receptor is crucial for body weight and bone mass regulation in mammals through hypothalamic effects on satiety and energy expenditure. Meanwhile, research data supports a leptin receptor activation model based on ligand-induced conformational changes.
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Molecular Weight
- 121 kDa
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Gene ID
- 3953
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NCBI Accession
- NP_002294
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UniProt
- P48357
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Pathways
- JAK-STAT Signaling, AMPK Signaling, Feeding Behaviour
Target
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