Patched 1 Protein (PTCH1) (DYKDDDDK Tag)
Quick Overview for Patched 1 Protein (PTCH1) (DYKDDDDK Tag) (ABIN2712353)
Target
See all Patched 1 (PTCH1) ProteinsProtein Type
Origin
Source
Application
Purity
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Purification tag / Conjugate
- This Patched 1 protein is labelled with DYKDDDDK Tag.
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Characteristics
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- Recombinant human PTCH1 (C-term DDK tag, transcript variant 1b) protein expressed in Sf9 cells.
- Produced with end-sequenced ORF clone
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Patched 1 (PTCH1) (AA 1-1447) protein (His tag)
custom-made PTCH1 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Patched 1 (PTCH1) (AA 1-1434) protein (His tag)custom-made PTCH1 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Patched 1 (PTCH1) (AA 1-183) protein (GST tag)PTCH1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Patched 1 (PTCH1) (AA 841-940) protein (GST tag)PTCH1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
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Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays -
Comment
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The tag is located at the C-terminal.
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Restrictions
- For Research Use only
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Concentration
- 50 μg/mL
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Buffer
- 50 mM Tris-HCl, pH 8.0, 100 mM glycine, 10 % glycerol. Store at -80C. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions.
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Storage
- -80 °C
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Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- Patched 1 (PTCH1)
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Alternative Name
- Ptch1
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Background
- This gene encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of this gene have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently.
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Molecular Weight
- 30.4 kDa
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NCBI Accession
- NP_000255
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Pathways
- Hedgehog Signaling, Carbohydrate Homeostasis, Tube Formation
Target
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