CYP7A1 Protein (Myc-DYKDDDDK Tag)
Quick Overview for CYP7A1 Protein (Myc-DYKDDDDK Tag) (ABIN2712786)
Target
See all CYP7A1 ProteinsProtein Type
Origin
Source
Application
Purity
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Purification tag / Conjugate
- This CYP7A1 protein is labelled with Myc-DYKDDDDK Tag.
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Characteristics
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- Recombinant human CYP7A1 protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
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Cytochrome P450, Family 7, Subfamily A, Polypeptide 1 (CYP7A1) (AA 179-277) protein (GST tag)
CYP7A1 Origin: Human Host: Wheat germ Recombinant AP, AA, ELISA, WB
Cytochrome P450, Family 7, Subfamily A, Polypeptide 1 (CYP7A1) proteinCYP7A1 Origin: Mouse Host: Escherichia coli (E. coli) Recombinant > 95 % WB, SDS, ELISA, IP
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Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays -
Comment
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The tag is located at the C-terminal.
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Restrictions
- For Research Use only
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Concentration
- 50 μg/mL
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Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
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Storage
- -80 °C
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Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- CYP7A1 (Cytochrome P450, Family 7, Subfamily A, Polypeptide 1 (CYP7A1))
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Alternative Name
- Cyp7a1
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Background
- This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway in the liver, which converts cholesterol to bile acids. This reaction is the rate limiting step and the major site of regulation of bile acid synthesis, which is the primary mechanism for the removal of cholesterol from the body. Polymorphisms in the promoter of this gene are associated with defects in bile acid synthesis.
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Molecular Weight
- 57.5 kDa
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NCBI Accession
- NP_000771
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Pathways
- Steroid Hormone Biosynthesis, Carbohydrate Homeostasis, Regulation of Lipid Metabolism by PPARalpha
Target
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