Caspase 3 Protein (CASP3) (Myc-DYKDDDDK Tag)
Quick Overview for Caspase 3 Protein (CASP3) (Myc-DYKDDDDK Tag) (ABIN2713205)
Target
See all Caspase 3 (CASP3) ProteinsProtein Type
Origin
Source
Application
Purity
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Purification tag / Conjugate
- This Caspase 3 protein is labelled with Myc-DYKDDDDK Tag.
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Characteristics
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- Recombinant human Caspase-3 (transcript variant beta) protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
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Caspase 3 (CASP3) (AA 29-277) protein (His-IF2DI Tag)
CASP3 Origin: Mouse Host: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Caspase 3 (CASP3) (AA 1-277) protein (GST tag)CASP3 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Caspase 3 (CASP3) (AA 176-277) proteinCASP3 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 80% by SDS-PAGE SDS
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Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays -
Comment
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The tag is located at the C-terminal.
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Restrictions
- For Research Use only
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Concentration
- 50 μg/mL
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Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
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Storage
- -80 °C
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Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- Caspase 3 (CASP3)
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Alternative Name
- Caspase-3
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Background
- This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.
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Molecular Weight
- 31.4 kDa
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NCBI Accession
- NP_116786
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Pathways
- Apoptosis, Caspase Cascade in Apoptosis, Sensory Perception of Sound, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Activated T Cell Proliferation
Target
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