BIN1 Protein (Transcript Variant 9) (Myc-DYKDDDDK Tag)

Catalog No. ABIN2715268

This Recombinant BIN1 protein is expressed in HEK-293 Cells.

Quick Overview for BIN1 Protein (Transcript Variant 9) (Myc-DYKDDDDK Tag) (ABIN2715268)

Target: BIN1 (Bridging Integrator 1 (BIN1))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Application: Antibody Production (AbP), Standard (STD)

Purity: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Product Details

Protein Characteristics: Transcript Variant 9

Purification tag / Conjugate: This BIN1 protein is labelled with Myc-DYKDDDDK Tag.

Characteristics:

• Recombinant human BIN1 / AMPHL (transcript variant 9) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Target Details

Target: BIN1 (Bridging Integrator 1 (BIN1))

Alternative Name: Bin1,amphl

Background: This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in several transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.

Molecular Weight: 48.1 kDa

NCBI Accession: NP_647600