Fibulin 5 Protein (FBLN5) (Myc-DYKDDDDK Tag)

Catalog No. ABIN2721183

This Recombinant Fibulin 5 protein is produced in HEK-293 Cells. There is 1 publication available.

Quick Overview for Fibulin 5 Protein (FBLN5) (Myc-DYKDDDDK Tag) (ABIN2721183)

Target: Fibulin 5 (FBLN5)

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Application: Antibody Production (AbP), Standard (STD)

Purity: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Product Details

Purification tag / Conjugate: This Fibulin 5 protein is labelled with Myc-DYKDDDDK Tag.

Characteristics:

• Recombinant human Fibulin-5 protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

References

Sideek, Menz, Parsi, Gibson: "LTBP-2 competes with tropoelastin for binding to fibulin-5 and heparin, and is a negative modulator of elastinogenesis." in: Matrix biology : journal of the International Society for Matrix Biology, Vol. 34, pp. 114-23, (2014) (PubMed).

Target Details

Target: Fibulin 5 (FBLN5)

Alternative Name: Fibulin-5

Background: The protein encoded by this gene is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling. Defects in this gene are a cause of autosomal dominant cutis laxa, autosomal recessive cutis laxa type I (CL type I), and age-related macular degeneration type 3 (ARMD3).

Molecular Weight: 47.8 kDa

NCBI Accession: NP_006320

Pathways: SARS-CoV-2 Protein Interactome