GRB2 Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag)
Quick Overview for GRB2 Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag) (ABIN2722229)
Target
See all GRB2 ProteinsProtein Type
Origin
Source
Application
Purity
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Protein Characteristics
- Transcript Variant 1
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Purification tag / Conjugate
- This GRB2 protein is labelled with Myc-DYKDDDDK Tag.
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Characteristics
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- Recombinant human GRB2 / ASH (transcript variant 1) protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
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Growth Factor Receptor-Bound Protein 2 (GRB2) (AA 1-217) protein (His tag)
custom-made GRB2 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Growth Factor Receptor-Bound Protein 2 (GRB2) (AA 1-217) protein (His tag)custom-made GRB2 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Growth Factor Receptor-Bound Protein 2 (GRB2) (AA 1-217) protein (GST tag)GRB2 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
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Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays -
Comment
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The tag is located at the C-terminal.
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Restrictions
- For Research Use only
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Concentration
- 50 μg/mL
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Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
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Storage
- -80 °C
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Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- GRB2 (Growth Factor Receptor-Bound Protein 2 (GRB2))
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Alternative Name
- Grb2,ash
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Background
- Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death. [UniProtKB/Swiss-Prot Function]
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Molecular Weight
- 25 kDa
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NCBI Accession
- NP_002077
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Pathways
- RTK Signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Actin Filament Polymerization, Hepatitis C, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, EGFR Downregulation
Target
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