Quick Overview for NLRP2 Protein (Myc-DYKDDDDK Tag) (ABIN2726786)
Target
See all NLRP2 ProteinsProtein Type
Origin
Source
Application
Purity
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Purification tag / Conjugate
- This NLRP2 protein is labelled with Myc-DYKDDDDK Tag.
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Characteristics
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- Recombinant human NALP2 protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
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NLR Family, Pyrin Domain Containing 2 (NLRP2) (AA 1-1062) protein (His tag)
custom-made NLRP2 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
NLR Family, Pyrin Domain Containing 2 (NLRP2) (AA 1-1062) protein (GST tag)NLRP2 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA
NLR Family, Pyrin Domain Containing 2 (NLRP2) (AA 1-846) protein (GST tag)NLRP2 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA
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Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays -
Comment
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The tag is located at the C-terminal.
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Restrictions
- For Research Use only
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Concentration
- 50 μg/mL
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Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
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Storage
- -80 °C
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Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- NLRP2 (NLR Family, Pyrin Domain Containing 2 (NLRP2))
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Alternative Name
- Nalp2
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Background
- This gene is a member of the nucleotide-binding and leucine-rich repeat receptor (NLR) family, and is predicted to contain an N-terminal pyrin effector domain (PYD), a centrally-located nucleotide-binding and oligomerization domain (NACHT) and C-terminal leucine-rich repeats (LRR). Members of this gene family are thought to be important regulators of immune responses. This gene product interacts with components of the IkB kinase (IKK) complex, and can regulate both caspase-1 and NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells) activity. The pyrin domain is necessary and sufficient for suppression of NF-kB activity. An allelic variant (rs147585490) has been found that is incapable of blocking the transcriptional activity of NF-kB. Alternative splicing results in multiple transcript variants encoding different isoforms.
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Molecular Weight
- 120.3 kDa
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NCBI Accession
- NP_060322
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Pathways
- Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Inflammasome
Target
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