Nicastrin Protein (NCSTN) (Myc-DYKDDDDK Tag)

Catalog No. ABIN2727295

This Recombinant Nicastrin protein is expressed in HEK-293 Cells.

Quick Overview for Nicastrin Protein (NCSTN) (Myc-DYKDDDDK Tag) (ABIN2727295)

Target: Nicastrin (NCSTN)

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Application: Antibody Production (AbP), Standard (STD)

Purity: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Product Details

Purification tag / Conjugate: This Nicastrin protein is labelled with Myc-DYKDDDDK Tag.

Characteristics:

• Recombinant human Nicastrin protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Target Details

Target: Nicastrin (NCSTN)

Alternative Name: Nicastrin

Background: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex. [UniProtKB/Swiss-Prot Function]

Molecular Weight: 75.2 kDa

NCBI Accession: NP_056146

Pathways: Notch Signaling, Neurotrophin Signaling Pathway